EGF and neoplasm: In contrast to the findings by Bøe et al. [164], Oliveira and co-workers [169] also demonstrated good effects of PCI for lipofectamine mediated siRNA delivery, and most notably were able to show that this combination also could give strong downregulation of EGF receptor expression in vivo, leading to tumour growth retardation in an EGF dependent tumour model [170].