TNF and chronic myelogenous leukemia, BCR-ABL1 positive: Compound 257 dose-dependently down-regulated TNFα (Tumor Necrosis Factor) -induced NF-κB (Proteins that can regulate gene expression) activity in human chronic myeloid leukemia cells with an IC50 of 38.5 ± 1.2 μM [88,89,90].