PTEN and neoplasm: The majority of p53 tumorigenic mutations are of the missense variety (http://p53.iarc.fr), as opposed to the nonsense, frameshift, and deletion types that predominate in other tumor suppressors such as BRCA1/2 (http://arup.utah.edu/database/BRCA), retinoblastoma-1 (http://rb1-lovd.d-lohmann.de), and PTEN (http://www.lovd.nl/PTEN).