TSG101 and neoplasm: In support of a tumor-suppressive role of TSG101, Moberg and coworkers [66] reported that lack of the TSG101 ortholog Erupted in Drosophila causes excessive cell growth, albeit in a non- cell- autonomous manner through the expression of the Notch target gene Unpaired, which is the secreted ligand that stimulates JAK/STAT signaling in the fly.