Decreased pAKT1-S473 phosphorylation after LASP1 depletion has been observed before in several tumor cell lines, glioblastoma [21], gall bladder [22] and nasopharyngeal carcinoma [23], while LASP1 overexpression induces phosphorylation in colorectal cancer cells [24] and non-small cell lung cancer [25]. Here, LASP1 is linked to colorectal cancer.