In addition, activation of CXCR4 in breast cancer cells facilitates nuclear translocation of LASP1 and an association of the protein with the transcription factor Snail, associated with epithelial-to-mesenchymal transition (EMT), and the protein complex UHRF1-DNMT1-G9a, involved in epigenetic modulation, is observed [14]. The gene discussed is LASP1; the disease is breast carcinoma.