Based on the previous data showing a LASP1-mediated PI3K/AKT1 activation [22,24,34] and our own findings demonstrating overexpression of LASP1 in breast cancer cells [35] and in CML [11], we wanted to address whether there is a direct regulation of AKT1 by LASP1 in these cells. This evidence concerns the gene LASP1 and breast cancer.