Parathyroid hormone (PTH) is a uremic toxin, high levels of which are associated not only with the classic hallmarks of bone disease, and are characterized by an increase in calcium, phosphate and FGF-23, all of them associated with an increased mortality, but also with anemia, hypertension, neuromyopathy, dysfunction of the peripheral and central nervous systems, and various metabolic effects, including dyslipidemia and impaired insulin secretion [10,11,12,13,14,15,16,17,18,19,20,21,22]. The gene discussed is PTH; the disease is metabolic syndrome.