TRBV16 and viral infectious disease: Although these results may not adapt to other EV71 infection mouse models directly [61,62,63] and could not completely reflect natural situations in human beings due to the limited experimental mouse model and bioinformatic prediction, these findings could partly broaden our knowledge in EV71 pathogenesis and provide an insight in the anti-viral therapy development potentially via manipulating expanded TCRβ CDR3 clones in virus infection.