In particular, the loss of heterozygosity (LOH) at the M6P/IGF2R gene locus on 6q26–27 chromosome seemed to be associated with the invasiveness of breast cancers, while M6P/IGF2R point mutations were identified in hepatoma, gastrointestinal (mainly associated with microsatellite instability) and prostate tumors [84]. This evidence concerns the gene IGF2R and breast cancer.