Both mimotopes elicited Abs capable of triggering (i) cellular and complement-dependent cytotoxic effects against EGFR-expressing cells, (ii) EGFR internalization, and (iii) dose-dependent inhibition of proliferation in the EGFR-overexpressing human squamous carcinoma cell line A431 [35]. This evidence concerns the gene EGFR and squamous cell carcinoma.