Variants with AF ~50% in both tissue and matching cfDNA from blood were detected in: BRCA1 (patient 4; Figure 1B and Table 1), BRCA2 (patient 9; Figure 1B and Table 1) and TP53 (patient 14; Figure 1B and Table 2), all of which were putative germline variants (AF ~ 50% in cfDNA and paired tissue). Here, BRCA2 is linked to atrial fibrillation.