BRCA1 and BRCA2 germline pathogenic variants were found in 7.3% of the IBC patients, 6.3% had a mutation in other cancer genes (PALB2, CHEK2, ATM and BARD1), and 1.6% had a germline pathogenic variant in other genes not related with breast cancer [46]. This evidence concerns the gene PALB2 and breast cancer.