IL15 and hepatocellular carcinoma: On the basis of the successful construction of human interleukin-15 gene-modified NKL cells (NKL-IL15) in the research report of Jiang et al. [99] the female BALB/c xenograft nude mice (six weeks old) were used as an experimental animal model to confirm its quite strong inhibitive action to the growth of transplanted human hepatocellular carcinoma.