An exciting novel research results also had been shown that the NK cells with positive CD56bright located in human hepatic sinuses had effective cytotoxicity against SNU398 hepatoma cells through multiple signaling pathways (such as high expression in NKG2D, NKp46, TRAIL, FasL, and others), which were very helpful for the immunotherapy of hepatocellular carcinoma [66]. This evidence concerns the gene KLRK1 and hepatocellular carcinoma.