MICA and neoplasm: Through the adhering receptor, NKG2D recognized specifically the major histocompatibility complex class I polypeptide-related molecule A (MIC-A), molecule B (MIC-B), and MHC-I related molecules UL16 binding proteins (ULBPs) [18,19] on the surface of multiple tumor cells, which subsequently plays a pivotal cytotoxic effect on the tumor cells.