The rG7S-MICA had a high affinity with the antibody and could effectively enrich NK cells to the tumor-bearing site of liver cancer in nude mice, and could enhance the anti-tumor activity by promoting the release of IFN-γ and TNF-α from NK cells via the MICA-NKG2D/Fc-FcR pathway. The gene discussed is IFNG; the disease is liver cancer.