In order to clarify that NKG2D could promote the secretion of IFN and play an inhibitory role in hepatocellular carcinoma cells, the detailed experimental research data on Wu et al. [72] had been found that the natural killer cell dysfunction induced by monocytes/macrophages in local hepatocellular carcinoma tissues was mediated by the interaction of CD48/2B4. The gene discussed is KLRK1; the disease is hepatocellular carcinoma.