However, in a chronic social defeat mouse model of depression, it was reported that the administration of the HDAC inhibitors suberoylanilide hydroxamic acid (SAHA) and MS-275 in the nucleus accumbens resulted in increased acetylation of the histone H3K14; an effect accompanied by a significant antidepressant-like effect, including decreased immobility in the FST [19]. This evidence concerns the gene HDAC9 and major depressive disorder.