From the reports European Uremic Toxin Work Group, sclerostin was found to be positively associated with a decline of eGFR, phosphate, HDL, interleukin 6, CRP, free indoxyl sulfate, p-cresyl sulfate, and cfPWV, which indicated its link with inflammation, vascular damages, and bone diseases of CKD patients [34]. Here, SOST is linked to chronic kidney disease.