SFRP1 and colorectal carcinoma: The method is demonstrated by the identification of 74 genes that are epigenetically silenced in CRC cells, including identification of methylation silencing of SFRP1 and its families such as SFRP2, SFRP4, and SFRP5. This patent covers three categories, which are C12Q1/6886 nucleic acid products used in the analysis of nucleic acids, C12Q1/6809 methods for determination or identification of nucleic acids involving differential detection, and C12Q2600/154 methylation markers.