REN and diabetic cardiomyopathy: Renin antagonist drugs have been to protect against diabetic cardiomyopathy.62,63 Sildenafil, a selective phosphodiesterase type 5 inhibitor and vasodilator, was recently shown to improve myocardial function, cardiac remodeling, and some circulatory markers of cardiac inflammation in patients with diabetic cardiomyopathy.64 Trials are needed to study the role of sildenafil in diabetic cardiomyopathy.