The therapeutic effect of adenosine on experimentally induced colitis was reflected in its ability to decrease the AA-induced hyperemia and hemorrhage, disruption of intestinal epithelium, infiltration of leukocytes into colon and rectum, AA-increased NF-kB immunoexpression, and AA-elevated TNF-α in both plasma and rectum tissues, MDA and PTX3 levels in plasma. Here, TNF is linked to colitis.