In this work we studied the three types of circulating monocytes and ILC2s, and the elevation of β2AR expression on intermediate monocytes as estimators of chronic low-grade inflammation in individuals with obesity, We analysed its associations with energy expenditure, anthropometry, hormonal and metabolic variables before and after of dietary restriction. This evidence concerns the gene ADRB2 and obesity due to melanocortin 4 receptor deficiency.