The glial targets that we focused upon play an important role in the pathogenesis of neurological diseases, especially for documenting neuroinflammation (Iba1+ and CD68+ microglia), astrocytosis (GFAP+ astrocytes), and disruption of myelination (NG2+ and O4+ OPCs, MBP and myelin PLP+ mature oligodendrocytes, Olig2+ all oligodendrocytes). The gene discussed is PLP1; the disease is nervous system disorder.