TRPV4 and obesity due to melanocortin 4 receptor deficiency: Collectively, after mechanical ventilation for 4 h, the injury of the pulmonary microvascular barrier, the pulmonary inflammatory response, and the expression of TRPV4 were alleviated in HFD-induced obese mice compared with that in NCD normal mice, leading us to further explore the impact of obesity on VILI and its potential mechanisms.