As mitochondrial dysfunction plays a crucial role in energy homoeostasis, metabolism and signalling,33 and activating the LKB1/AMPK/Sirt1 pathway prevents the development of cardiomyopathy by improving lipid and fatty acid metabolism,34 mitochondrial energy metabolism‐related AMPK/Sirt1 pathway was investigated to evaluate whether HG/[6]‐GR had potential effect on LKB1/AMPK/Sirt1 axis and its downstream targets. Here, SIRT1 is linked to cardiomyopathy.