Notch signalling affects a variety of cellular processes, including maintenance of undifferentiated states, participating in cell fate decisions, inducing terminal differentiation and other functions involved in the progression of cancer.25 Notch was originally found to be an oncogene in T cell leukaemia 26 and mediates TGF‐α‐induced changes in epithelial differentiation during pancreatic tumorigenesis.27 NOTCH3 is more strongly expressed in endometrial cancer cells than in normal endometrial gland cells and is associated with poor prognosis.28 The gene discussed is NOTCH3; the disease is cancer.