Furthermore, it has been reported that high levels of the human homologue of Pros, PROX1, exacerbate glioblastoma (Elsir et al., 2010; Goudarzi et al., 2018; Roodakker et al., 2016; Xu et al., 2017), arguing against PROX1 expression as a therapeutic strategy. Here, PROX1 is linked to glioblastoma.