STXBP1 and Epileptic encephalopathy: In humans, STXBP1 de novo heterozygous mutations cause several of the most severe forms of epileptic encephalopathies including Ohtahara syndrome (Saitsu et al., 2008; Saitsu et al., 2010), West syndrome (Deprez et al., 2010; Otsuka et al., 2010), Lennox-Gastaut syndrome (Carvill et al., 2013; Allen et al., 2013), Dravet syndrome (Carvill et al., 2014), and other types of early-onset epileptic encephalopathies (Deprez et al., 2010; Mignot et al., 2011; Stamberger et al., 2016).