STXBP1 and Encephalopathy: The mutant mice made more repetitive nose pokes than WT mice across many holes (Figure 4G), indicating that Stxbp1 haploinsufficiency in mice causes abnormal stereotypy and repetitive behaviors, a psychiatric feature observed in about 20% of the STXBP1 encephalopathy patients (Stamberger et al., 2016).