Syntaxin-binding protein 1 (STXBP1, also known as MUNC18-1) is one such example because its molecular and cellular functions are well understood (Rizo and Xu, 2015), its pathogenic variants are emerging as prevalent causes of multiple neurodevelopmental disorders (Stamberger et al., 2016), and yet it remains unclear how its dysfunction causes disease. Here, STXBP1 is linked to neurodevelopmental disorder.