BHLHE41 and neoplasm: Dysregulation of BHLHE41 transcription levels has been characterized as a marker of the progression of several cancers.8, 16, 17, 18, 19, 20, 21, 22, 23 Recent studies indicate that BHLHE41 is involved in regulating tumour migration and invasion.5, 6, 19, 24 Asanoma et al19 demonstrated that BHLHE41 suppressed tumour invasion and metastasis in endometrial cancer by inhibiting TWIST1 transcription.