BHLHE41 was demonstrated to be a crucial regulator of the invasive and metastatic phenotype in triple‐negative breast cancer and suppressed metastasis by promoting the degradation of hypoxia‐inducible factors in MDA‐MB‐231 cells.8 Thus far, most researchers believe that BHLHE41 plays a role in suppressing cell invasion and metastasis in tumour progression. The gene discussed is BHLHE41; the disease is neoplasm.