The most distinctive alterations in the gut microbiome composition observed in AD is the decreasing abundance of anti‐inflammatory bacterial species such as Bifidobacterium breve strain A1 and increasing abundance of pro‐inflammatory bacterial species such as Firmicutes and Bacteroidetes (Bostanciklioglu 2019), with both Bifidobacterium regulated by the Adnp genotype and by NAP (above and (Escher et al. 2018)) and also dysregulated in ASD (Xu et al. 2019). The gene discussed is ADNP; the disease is Alzheimer disease.