Furthermore, we constructed a PPI network of these differently expressed RBPs and got the top ten hub genes including BOP1, GNL3, WDR12, NOP2, BYSL, BRIX1, DCAF13, TFB2M, NSUN2 and DKC1. Among these genes, NOP2, also known as p120, is found highly expressed in lung adenocarcinoma tissue and negatively associated with patients prognosis (Saijo et al., 2001; Uchiyama et al., 1997). This evidence concerns the gene WDR12 and lung adenocarcinoma.