It is transcriptional silencing in human breast cancer due to hypermethylation modification of its promoter (Pique et al., 2019); RBP SORBS2 inhibit liver cancer carcinogenesis and metastasis by regulating the stability of RORA (Han, Huang & Zhang, 2019); AGO2 promote tumor development by up-regulating the expression of oncogenic miR-19b (Zhang et al., 2019); RBP KHSRP promotes lung cancer cell proliferation, migration, and invasion (Yan et al., 2019); HuR by regulating related mRNA stability to induce tumor cell proliferation and metastasis of stomach carcinoma (Xie et al., 2019b). This evidence concerns the gene RORA and neoplasm.