In accordance with the immunohistochemistry results from the Human Protein Atlas database, we found that the expression of hub RBPs BOP1, GNL3, WDR12, DCAF13, IGF2BP3, and IGF2BP1 were obviously elevated in lung carcinoma compared with normal lung tissues, while KHDRBS2 and SMAD9 were significantly decreased in tumor tissues (Fig. 4). Here, SMAD9 is linked to lung carcinoma.