SCN5A and Ventricular arrhythmia: Mutation of the SCN5A gene, which encodes the pore‐forming region of the cardiac sodium channel, is the most common gene mutation found in BrS patients, with the impaired sodium channels predisposing patients to phase 2 reentry precipitating ventricular arrhythmias.6, 47 However, this mutation was only found in less than 30% of the patients with BrS55, 60 and only shown to be associated with MAE in Asian populations but not Caucasian populations.20, 50 Most patients with BrS do not have an identifiable mutation.