MSC transplantation reversed liver fibrosis by downregulating the serum levels of IL-17, IL-2 and IL-6 and the expression of IL-17A and IL-17RA in the liver, which was accompanied by downregulation of the expression of STAT3, p-STAT3, P-SMAD3 and TGF-βR2 90. This evidence concerns the gene STAT3 and Hepatic fibrosis.