Recently, in experiments performed by Ju et al found that hypoxia induces the expression of integrins, which bind to collagen including ITGA1, to promote tumor metastasis in female NOD-SCID or BALB/c mice (age of 5-7 week) 32, thus regarding there is no strong sex-linked in the CRC. This evidence concerns the gene ITGA1 and colorectal carcinoma.