Boudjadi et al demonstrated that integrin α1β1 was positively correlated with CRC cell invasion and proliferation by activating the focal adhesion kinase (FAK)-src/p130Cas-JNK signaling cascades 6, 12, 14, 15 and the Ras/MEK/ERK signaling pathway 16. The gene discussed is MAP2K7; the disease is colorectal carcinoma.