ITGA1 and cancer: In this study, we investigated the roles of ITGA1 in CRC, by detecting its expression in CRC tissues, serum and cancer cell lines, evaluating the correlation of ITGA1 with pathological features and circulating CA199, analyzing the biology of ITGA1 in CRC by regulating the Ras/Erk signaling pathway, and examining its effects on the progressive properties and tumorigenicity in CRC cells.