Intriguingly, our mRNA expression profiles of human colorectal tissues and precancerous detecting with the Affymetrix Human Genome U133 Plus 2.0 Array shown that the abundance of ITGA1 transcript was dramatically increased in tumor tissues compared to the paired adjacent normal non-tumor tissues of CRC patients (p = 1.95E-17). The gene discussed is ITGA1; the disease is neoplasm.