To investigate the impact of ITGA1 in the tumorigenicity of CRC cells in vivo, an equal number of NCM460 cells with LV-ITGA1 and SW480 cells with LV-shITGA1 were injected subcutaneously into nude mice and employed for evaluating the oncogenic role of ITGA1 in CRC in a xenograph tumorigenic model in vivo (Fig. 7). The gene discussed is ITGA1; the disease is colorectal carcinoma.