Recently, Chattaragada et al. found FAM49B acts as a suppressor of cancer cell proliferation and invasion in pancreatic ductal adenocarcinoma (PDAC) by regulating tumor mitochondrial redox reactions and metabolism, and Shang et al. found that FAM49B inhibits T cell activation by repressing Rac activity and modulating cytoskeleton reorganization 29, 30. Here, CYRIB is linked to pancreatic ductal adenocarcinoma.