Procollagen processing of tolloid-like proteases exerts a rate-limiting effect during myocardial fibrosis, whereas sFRP2 enhances procollagen C protease activity in mammalian bone morphogenetic protein 1 (BMP1), resulting in the conversion of procollagen to collagen in the extracellular matrix, ultimately promoting collagen deposition and fibrosis 41, 42. The gene discussed is BMP1; the disease is Myocardial fibrosis.