SMYD3 was also associated with ankyrin repeat and KH domain-containing protein 1 (ANKHD1) that regulate the initiation, progression and metastasis in HCC36 Although our data underline the significance of the SMYD3 VNTR 3/3 genotype and SMYD3 overexpression in HBV-related HCC development, the interaction between HBV and SYMD3 needs to be investigated further. The gene discussed is ANKHD1; the disease is hepatocellular carcinoma.