Following studies on the biological processes underlying the increase in miR-4435 levels in mutant UQCRB-expressing cell lines in transcriptional levels and correlation of miR-4435 with the progression and metastasis of CRC in vivo will help to understand the biological and clinical values of UQCRB-miR-4435-TIMP3-CRC links. Here, TIMP3 is linked to colorectal carcinoma.