We and our collaborators along with other groups have identified TF as an angiogenesis-specific receptor on VEGF-stimulated angiogenic microvascular endothelial models in vitro as well as in vivo in angiogenic VECs (the inner layer) of the pathological neovasculature of endometriosis, age-related macular degeneration (AMD) and solid cancers, including melanoma27,28, lung cancer29 and breast cancer29, and from tumor xenografts in mice and breast cancer tissues from patients14,16. This evidence concerns the gene TF and age-related macular degeneration.