Representative examples of NR4A1-occupied super enhancers that are repressed by DHE are shown in Fig. 1J and Supplemental Fig. 4 and include those associated with AML oncogenes MYC (Fig. 1J), CDK6 and BCL2, as well as IRF8, MEF2D, P2RY2 and ETV6 (Supplemental Fig. 4). This evidence concerns the gene IRF8 and acute myeloid leukemia.