Representative examples of NR4A1-occupied super enhancers that are repressed by DHE are shown in Fig. 1J and Supplemental Fig. 4 and include those associated with AML oncogenes MYC (Fig. 1J), CDK6 and BCL2, as well as IRF8, MEF2D, P2RY2 and ETV6 (Supplemental Fig. 4). The gene discussed is MYC; the disease is acute myeloid leukemia.