As predicted by the comparative ability of DHE and JQ1 to dismiss MED1 and repress transcription of select SE-associated oncogenes including MYC, we found that DHE and JQ1 showed comparable efficacy in repressing SE-dependent expression of MYC in vitro, and suppressing growth of MYC-dependent MLL-rearranged human AML in vivo in a mouse xenograft model. The gene discussed is MED1; the disease is acute myeloid leukemia.