To determine the influence of lnc-Lfar1 on the pyroptosis during liver fibrosis process in vivo, we assessed pyroptosis by the level of key proteins regulating pyroptosis including NLRP3, pro-caspase-1, cleaved caspase1, GSDMD and GSDMD-N, mature IL-1β, IL-18 and lactate dehydrogenase (LDH) release. This evidence concerns the gene IL18 and Hepatic fibrosis.