Since NF-ĸB has been reported to be a critical signaling involved in inflammatory recruitment and liver fibrosis, and activation of NF-ĸB leads to constitutive overproduction of proinflammatory cytokines, including IL-1β, TNF-α, and MCP-120,21, the effect of lnc-Lfar1 on NF-ĸB signaling was therefore investigated. The gene discussed is IL1B; the disease is Hepatic fibrosis.