Given the U2AF-homology motif (UHM) of PUF60 directly interacting with the WD-repeat of SAP155 (SF3B1)13, FIRΔexon2 expressed in cancer cells by alternative splicing of FIR pre-mRNA, which is dysregulated by the FIR-SAP155 interaction9. This evidence concerns the gene SF3B1 and cancer.