We found that a subset of A1, A2, and pan-astrocytic genes were significantly increased in HD, including GFAP, CD44, OSMR, FKBP5, STEAP4, and CXCL10 for pan-reactive genes, C3, SRGN, and GBP2 for A1 genes, and EMP1, CD14, and CD109 for A2 genes. This evidence concerns the gene GFAP and Huntington disease.