TBR1 and neoplasm: Taking into account that our analysis of KIRC data also revealed a significant tumor-specific reduction of TBR1 mRNA expression and biometrical data provided by the UCSC genome browser report the presence of microRNA response elements, from a theoretical point of view epigenetic alteration of both transcriptional as well as post-transcriptional control of TBR1 mRNA expression in RCC can be considered as possible starting points for functional analyses.