Intriguingly, in addition to its direct regulatory roles in HCC cells, our results also showed that the CHD4/NuRD complex inversely correlated with CD8 T cell and DC cell infiltration in HCC, suggesting that the CHD4/NuRD complex not only plays direct regulatory roles in HCC cells, but also has an impact on the immune microenvironment of HCC. This evidence concerns the gene CHD4 and hepatocellular carcinoma.