Intriguingly, in addition to its direct regulatory roles in HCC cells, our results also showed that the CHD4/NuRD complex inversely correlated with CD8 T cell and DC cell infiltration in HCC, suggesting that the CHD4/NuRD complex not only plays direct regulatory roles in HCC cells, but also has an impact on the immune microenvironment of HCC. The gene discussed is CD8A; the disease is hepatocellular carcinoma.