To this end, we compared the gene expression profiles of the high_expression HCC samples to that of the low_expression HCC samples for each of the six subunits (CHD4, KDM1A, HDAC1, MTA3, RBBP4, RBBP7) of the NuRD complex, which are overexpressed in HCC and show prognostic value, to identify differentially expressed genes using DESeq2 package, an R/Bioconductor package. The gene discussed is CHD4; the disease is hepatocellular carcinoma.