FOXC1 and Axenfeld-Rieger syndrome: Other miR-204 target genes downregulated in HTM cells overexpressing miR-204 mimic include the fork-head box C1 transcription factor (FOXC1)—a causative gene for anterior segment dysgenesis known as Axenfeld-Rieger syndrome with a ~ 50% risk for high tension glaucoma—along with several downstream FOXC1-target genes, notably MEIS2 [188].