Third, miR-204 downregulation in age-related cataract and PCO suggest that miR-204 targets genes involved in EMT (e.g., αSMA) and oxidative stress (e.g., ALDH1A3), whereas miR-204 downregulation in congenital cataract implicated targeting of Meis2 [172–176]. This evidence concerns the gene ACTA1 and Age-related cataract.