In keeping with its role in vertebrate eye development, the first identified mutation in MIR204 has been found to underlie an inherited (autosomal dominant) pediatric form of bilateral retinal (rod-cone) dystrophy and iris coloboma with or without congenital cataract (RDICC, OMIM 616722) segregating in a 5-generation British family [83]. The gene discussed is MIR204; the disease is coloboma of iris.