SETD2 and cancer: Interestingly, we observed increased genomic instability in the primary tumor samples for the four cancers examined, when mutations occurred in the Jumanji domain compared to other positions in the gene (Fig. 6). Previous reports showed that tumors from patients with SETD2 gene mutations have low levels of genomic instability [29], thus we retrieved a subset of JMJD1B wild type patients with mutations in SETD2 from the four cancers types alluded above and compared the genomic instability between the two populations (SETD2 mutants vs. JMJD1B mutants) using one-way ANOVA tests.