We further characterized SetDB1 interactions by mass spectrometry from cytosolic extracts derived from HeLa cells and, in addition to known players in metabolizing newly synthesized histones, we identified a new interacting partner, the demethylase JMJD1B (also referred to as KDM3B), a candidate tumor suppressor [10] with H3K9me1/2 and H4R3me2 demethylase activities [2, 16] (Additional file 1: Figure S1). Here, KDM3B is linked to neoplasm.