EZH2 and Disorder of lipid metabolism: After ApoE−/− mice were challenged with a high-methionine diet for 16 weeks, the levels of Ezh2 and H3K27me3 were increased in their aortas, which promoted the accumulation of total cholesterol and triglycerides in foam cells, and miR-92a inhibited this HHcy-mediated lipid metabolism disorders by targeting Ezh2 [55].