Further investigation indicated that the Brg1/Brm and Ash2/Wdr5 complexes are recruited by MRTF-A to catalyze H3K4 methylation on the ET-1 promoter, which induces ET-1 transactivation in ECs to accelerate Ang II-induced cardiac hypertrophy and fibrosis [114]. Here, EDN1 is linked to cardiac hypertrophy.