DOT1L and anemia: In early mammalian erythropoiesis, histone methyltransferase Dot1l plays a critical role in controlling the number of circulating erythroid and myeloid cells, as indicated by Dot1l-mutant mice that developed more slowly and died between E10.5 and E13.5, displaying profound anemia, which was especially apparent in the small vessels of the yolk sac.