Mechanistically, Ezh2 induced DNA methyltransferase 1 (Dnmt1) expression, methyl CpG-binding protein-2 (MeCP2) recruitment, and the binding of Dnmt1 and MeCP2 to the ATP-binding cassette transporter A1 (Abca1) promoter, thereby promoting Abca1 gene DNA methylation, which inhibited Abca1 expression and accelerated atherosclerosis [53]. This evidence concerns the gene EZH2 and atherosclerosis.