In peripheral blood monocytes (PBMs) isolated from 44 T2DM patients and 24 age-matched controls, the T2DM patients showed higher SET7 expression levels than were shown by the controls, and SET7 methylated H3K4me1 on the promoter of NF-κBp65 to accelerate its expression, resulting in ICAM-1 and MCP-1 secretion into plasma to induce oxidative stress and the inflammatory response [102]. The gene discussed is SETD7; the disease is type 2 diabetes mellitus.