SMYD2 and triple-A syndrome: For abdominal aortic aneurysm (AAA), Jones et al. identified four new AAA-specific risk loci, including 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG), via a meta-analysis of 6 genome-wide-associated study data sets and a validation study with a total of 10,204 cases and 107,766 controls [68].