Moreover, astroglia can express NLRP3 inflammasome and IL-1β under certain conditions, such as in SOD1 mouse model of amyotrophic lateral sclerosis (ALS) and human sporadic ALS patients, and amyloid β1–42-stimulated murine astrocytes [90, 91]. The gene discussed is IL1B; the disease is amyotrophic lateral sclerosis.