This dataset contains single cell data on over 150,000 CD8+ T cells isolated from 4 healthy donors, two of which were CMV positive, 44 dextramers were simultaneously used in each subject to isolate antigen specific T cells across viral infections (CMV (Cytomegalovirus), EBV (Epstein-Barr virus), HPV (Human papillomavirus), Influenza, HIV (Human immunodeficiency virus)), and cancer (e.g., MART, MAGE NY-ESO). Here, SEPTIN4 is linked to cancer.