In addition to the categorical analysis of HbA1c level, Model 1 included the following variables; age, male gender, number of diseased vessels, systolic blood pressure, LDL-C, HDL-C, blood glucose and number of years with diabetes (covariates other than gender male were assessed as continuous variables, one standard deviation higher or 1 year longer), while Model 2 included age (a continuous variable), male gender, use of beta-blockers, ejection fraction (a continuous variable), hemoglobin, blood glucose, eGFR (a continuous variable), number of years with diabetes and insulin use. The gene discussed is INS; the disease is diabetes mellitus.