Among the genes always selected by Model II, discriminating between tumor periphery neoplastic astrocytes and normal tumor periphery astrocytes, the epidermal growth factor receptor (EGFR), up-regulated in neoplastic periphery astrocytes over normal periphery astrocytes, is a previously reported significantly mutated gene in GBM [20, 21]. The gene discussed is EGFR; the disease is glioblastoma.