In keratinocytes, IL-17A upregulates the expression of various psoriasis-related cyto/chemokines and antimicrobial peptides, such as CXCL1, CXCL8, IL-36G, CCL20, IL-19, IL-17C, S100A7, S100A8, S100A9, LL-37, and defensin β 4A (DEFB4A) [157,169,173,188,189,190]. The gene discussed is CXCL8; the disease is psoriasis.