These include the propensity for NF2 tumours to be located in the posterior fossa while non-NF2 tumours tend to be located in the anterior or middle cranial fossae, and AKT1 E17K/TRAF7-mutant meningiomas commonly being of meningothelial or transitional histological subtypes while the KLF4-K409Q mutant tumours are often of the secretory subtype. The gene discussed is AKT1; the disease is meningioma.