The principal aims of this study are to (i) investigate the changes and behavior of PC-3 prostate cancer cells exposed to s-μg created by an RPM; (ii) test, based on previous findings, the hypothesis that exposure of PC-3 cells to s-μg induces the formation of MCS and alters the expression of genes related to angiogenesis, metastasis, the cytoskeleton, the ECM, and focal adhesions (FAs); and (iii) focus on the VEGF, MAPK, and PI3K/AKT/mTOR (PAM) signaling pathways. This evidence concerns the gene AKT1 and prostate carcinoma.